Histology, 12p status, and IMP3 expression separate subtypes in testicular teratomas
نویسندگان
چکیده
منابع مشابه
Experimental Production of Testicular Teratomas in Mice.
6Madsen (private communication) found that Mg ions lower the Km for 5'-AMP without affecting the Van. Owing to this effect, the inhibition by ATP is markedly diminished in the presence of this metal ion. Similarly, the effect of 5'-AMP on the interaction of phosphorylase with its substrates could be modified by the presence of Mg ions and result in different numerical values for kinetic paramet...
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PURPOSE The distinction of epidermoid cyst of the testis from teratoma is of critical importance because the former is benign and the latter is a malignant tumor that may have associated metastasis of either teratomatous or non-teratomatous germ cell tumor types. Chromosome 12p abnormalities are seen in the vast majority of testicular germ cell tumors of adults and are present in all histologic...
متن کاملClonal origin of metastatic testicular teratomas.
PURPOSE Testicular teratomas in adult patients are histologically diverse tumors that frequently coexist with other germ cell tumor (GCT) components. These mixed GCTs often metastasize to retroperitoneal lymph nodes where multiple GCT elements are frequently present in the same metastatic lesion. Neither the genetic relationships among the different components in metastatic lesions nor the rela...
متن کاملExperimental induction of testicular teratomas in dissociated-reaggregated chimaeric gonads.
Testicular teratomas can be experimentally induced in some strains of mice by grafting 12.5-day male genital ridges to the testes of adults. The grafts develop into testes and most of them have teratomas. The cells of 12.5-day foetal gonads were dissociated and the germ cells and somatic cells were separated. When germ cells were reaggregated with somatic cells and implanted in adult testes, th...
متن کاملTesticular tumours: histology, prevalence and epidemiology.
Sixty five testicular tumours in 27 years accounted for an average of 2-3 cases (specimens) per year. The estimated frequency was therefore 0.04% out of total 165,000 biopsies received during this period. Specimens were sent from surgical units of various hospitals of Karachi be sides Jinnah Postgraduate Medical Centre (JPMC). Sections prepared were stained with routine haematoxylin and eosin; ...
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ژورنال
عنوان ژورنال: Virchows Archiv
سال: 2020
ISSN: 0945-6317,1432-2307
DOI: 10.1007/s00428-020-02771-2